TGFB1/TGFβ1/TGF-β1, Human, Recombinant
货号： PCK091
Price： ￥14680 ￥6280 ￥3480 ￥1180 ￥23880
产品信息
| 产品形态 | 粉末 |
| 产品规格 | 500μg / 100μg / 50μg / 10μg / 1mg |
| 别名 | Transforming Growth Factor Beta-1;TGF-Beta-1;Latency-Associated Peptide;LAP;TGFB1;TGFB |
| 物种 | 人 |
| 表达宿主 | CHO Stable Cells |
| 序列信息 | Ala279-Ser390 |
| 检索号 | P01137 |
| 分子量 | 12.8 kDa |
| 表观分子量 | 13 kDa |
| 生物活性 | Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 4-40 pg/mL. |
| 纯度 | > 95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per 1 μg as determined by LAL test. |
| 储存条件 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输条件 | Ambient temperature or ice pack. |
| 有效期 | 12个月 |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 50 mM Glycine-HCl, 150 mM Nacl, pH 2.5. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 背景介绍 | Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease. |
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MICAL1 Mediates TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma by Activating Smad2/3(2025)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-025-01668-8
影响因子：1.800
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Heparin-binding epidermal growth factor-like growth factor (HB-EGF) activates p38 to affect pulmonary fibrosis(2024)
期刊：Regenerative Therapy
DOI：10.1016/j.reth.2024.05.002
影响因子：4.300
引用产品： HGF R/c-Met/HGFR (Glu25-Gly519), Human, Recombinant, TGFB1/TGFβ1/TGF-β1, Human, Recombinant
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High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT(2024)
期刊：Cancer Medicine
影响因子：4.000
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The silencing of lnc-NONHSAT071210 suppresses the proliferation, fibrosis, migration, and invasion of TGFβ1-treated lung epithelial cells(2022)
期刊：Annals of Translational Medicine
影响因子：3.616
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DNMT3B attenuated the inhibition of TET3 on epithelial-mesenchymal transition in TGF-β1-induced ovarian cancer by methylating the TET3 promoter(2022)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2022.100701
影响因子：2.100
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SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 Axis(2021)
期刊：Reproductive Sciences
DOI：10.1007/s43032-021-00690-4
影响因子：2.900
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miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury(2019)
期刊：Life Sciences
影响因子：6.100
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Q1:官网的因子都是不含动物成分的么？
我们公司的因子都是重组的，是不含动物源成分的。
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Q2:这个重组蛋白如果我想加入细胞里，用哪个溶解呢 ？因为随产品附赠了一管pbs和一管无菌水
首次复融使用无菌水，复融后如果还需要进一步稀释的话，使用含海藻糖的PBS进行稀释。
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