货号： CP-H042
Price： ￥8380
生长培养基： 人肝内胆管上皮细胞完全培养基(含FBS、生长添加剂、Penicillin、Streptomycin等)
产品信息
| 产品名称 | 人肝内胆管上皮细胞 | ||||||||||||||||||
| 组织来源 | 肝脏组织 | ||||||||||||||||||
| 产品规格 | 5×10^5Cells/T25 | ||||||||||||||||||
| 方法简介 | 普诺赛实验室分离的人肝内胆管上皮细胞采用胶原酶灌注消化法后，再用胶原酶-DNA酶联合消化，接种至预先包被鼠尾胶原的培养瓶中，通过上皮细胞专用培养基培养筛选制备而来，细胞总量约为5×105cells/瓶。 | ||||||||||||||||||
| 质量检测 | 普诺赛实验室分离的人肝内胆管上皮细胞经Cytokeratin-19免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。 | ||||||||||||||||||
| 培养信息 |
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A novel biomarker GATM suppresses proliferation and malignancy of cholangiocarcinoma cells by modulating the JNK/c-Jun signalling pathways(2024)
作者：Yi Yu, Wei Gan, Jianping Xiong, Junhe Li
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e37344
影响因子：3.4
引用产品： RBE 细胞, 人肝内胆管上皮细胞完全培养基, 特级胎牛血清, 人肝内胆管上皮细胞
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Nanofiber-based delivery of evodiamine impedes malignant properties of intrahepatic cholangiocarcinoma cells by targeting HDAC4 and restoring TPM1 transcription(2024)
作者：Zou Rui, Wang Yiyao, Cai Yaoqing, Xing Zhenming, Shao Yongfu, Li Duo, Qi Chunchun
期刊：Human Cell
DOI：10.1007/s13577-024-01105-7
影响因子：3.4
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A Novel Trojan Horse Nanotherapy Strategy Targeting the cPKM-STMN1/TGFB1 Axis for Effective Treatment of Intrahepatic Cholangiocarcinoma(2023)
作者：Zhi-Wen Chen, Feng-Ping Kang, Cheng-Ke Xie, Cheng-Yu Liao, Ge Li, Yong-Ding Wu, Hong-Yi Lin, Shun-Cang Zhu, Jian-Fei Hu, Cai-Feng Lin, Yi Huang, Yi-Feng Tian, Long Huang, Zu-Wei Wang, Shi Chen
期刊：Advanced Science
影响因子：15.1
引用产品： 人肝内胆管上皮细胞, 小鼠肝枯否细胞, 人肝内胆管上皮细胞完全培养基, 小鼠肝枯否细胞完全培养基
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The protective effect of forsythiaside A on 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver injury in mice: Based on targeted metabolomics and molecular biology technology(2023)
作者：Ke Fu, Shu Dai, Yanzhi Li, Cheng Ma, Xinyan Xue, Shenglin Zhang, Cheng Wang, Honglin Zhou, Yafang Zhang, Yunxia Li
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2023.166822
影响因子：6.2
引用产品： HL-7702 [L-02; LO2] 细胞, 人肝内胆管上皮细胞
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MUC1 induces the accumulation of Foxp3+ Treg cells in the tumor microenvironment to promote the growth and metastasis of cholangiocarcinoma through the EGFR/PI3K/Akt signaling pathway(2023)
作者：Guofeng Zhang, Ge Zheng, Haipeng Zhang, Ling Qiu
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110091
影响因子：5.6
引用产品： 人肝内胆管上皮细胞
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Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42(2023)
作者：Xifang Wang, Xiaomin Zhang, Jingying Sun, Yang Sun, Yuan Zhang, Li He, Ping Wang, Feng Li, Chao Sun
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116492
影响因子：3.8
引用产品： 特级胎牛血清, 青霉素-链霉素溶液 (双抗)，100×, HCCC-9810 细胞, 人肝内胆管上皮细胞, 人肝内胆管上皮细胞完全培养基
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Hsa_circ_0019054 up-regulates HIF1A through sequestering miR-340–5p to promote the tumorigenesis of intrahepatic cholangiocarcinoma(2022)
作者：Jintian Tang, Runjuan Tang, Peng Gu, Jing Han, Wukui Huang, Feng Xue
期刊：HUMAN & EXPERIMENTAL TOXICOLOGY
影响因子：3.3
引用产品： 人肝内胆管上皮细胞, RBE 细胞, HuCC-T1 细胞
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Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression.(2022)
作者：Sun J, Feng M, Zou H, Mao Y, Yu W
期刊：HISTOLOGY AND HISTOPATHOLOGY
影响因子：2.1
引用产品： RBE 细胞, HCCC-9810 细胞, 人肝内胆管上皮细胞
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RANK/RANKL Acts as a Protective Factor by Targeting Cholangiocytes in Primary Biliary Cholangitis(2019)
作者：Yanli Hao, Zhaolian Bian, Linling Ju
期刊：Digestive Diseases and Sciences
DOI：10.1007/s10620-019-05758-5
影响因子：3.1
引用产品： 人肝内胆管上皮细胞
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Q1:原代上皮细胞是否可以用除鼠尾胶原外的其他的包被试剂包被
理论上各种包被试剂都是具有增加吸附性的效果，鼠尾胶原蛋白I型是一种常用的细胞外基质成分，能够模拟体内细胞生长的真实环境，特别适合于促进上皮细胞等需要良好贴壁的细胞类型贴附和生长。上皮细胞在体内外都需要特定的细胞-细胞和细胞-基质相互作用才能正常增殖和分化，鼠尾胶原能够提供这样的有利基质，帮助细胞更好地粘附和伸展，从而维持正常的细胞功能和形态。
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