货号： CL-0480
Price： ￥1000 ￥1000
生长培养基： RPMI-1640[PM150110]+10% FBS[164210]+1% P/S[PB180120]
产品信息
| 产品名称 | PC-12 (Low differentiation)（大鼠肾上腺嗜铬细胞瘤细胞（低分化）） |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 多角形 |
| 冻存条件 |
冻存液：55% 基础培养基+40% FBS+5% DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:RPMI-1640[PM150110]+10% FBS[164210]+1% P/S[PB180120] 培养条件: 气相：空气，95%；CO₂，5%, 温度：37℃ |
| 培养方案B（可选） |
生长培养基: 培养条件: 气相：, 温度：37℃ |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 |
|
参考资料(来源文献)
| 背景描述 | PC-12(Low differentiation)细胞是来自能移植的雄性大鼠肾上腺嗜铬细胞瘤。PC-12(Low differentiation)细胞表达神经生长因子（NGF）受体，NGF可诱导产生神经表型。PC-12(Low differentiation)细胞不合成肾上腺素。 |
| 年龄（性别） | Male |
| 组织来源 | 肾上腺嗜铬细胞瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 嗜铬细胞瘤细胞 |
STR位点信息
STR鉴定图
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Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production(2024)
作者：Yang Jing, Yang Junqing, Luo Ying, Ran Dongzhi, Xia Rongsong, Zheng Qixue, Yao Peishuang, Wang Hong
期刊：Journal of Neuroimmune Pharmacology
DOI：10.1007/s11481-024-10136-8
影响因子：5.2
引用产品： PC-12 (High differentiation) 细胞
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Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy(2024)
作者：Hao Wu, Yicong Dong, Qiang Meng, Jingyi Jiang, Bojian Gao, Yutao Ren, Yong Liu, Huanfa Li, Changhe Wang, Hua Zhang
期刊：NEUROBIOLOGY OF DISEASE
影响因子：5.1
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Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification(2024)
作者：Zhiqiang Lu, Jingqi Yang, Xiaomeng Xu, Ruowen Liu, Songyi Lin
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2024.176430
影响因子：5.0
引用产品： PC-12 (Undifferentiated) 细胞, PC-12 (Undifferentiated)细胞专用培养基
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Insulin-Like Growth Factor Binding Protein 2 Drives Neurodegeneration in Parkinson's Disease: Insights From In?Vivo and In?Vitro Studies(2024)
作者：Jing An, Lulu Wen, Haiyang Yu, Zhongqi Bu, Juan Feng
期刊：CNS Neuroscience & Therapeutics
影响因子：4.8
引用产品： PC-12 (High differentiation) 细胞
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Guilu Erxian Jiao remodels dendritic spine morphology through activation of the hippocampal TRPC6-CaMKIV-CREB signaling pathway and suppresses fear memory generalization in rats with post-traumatic stress disorder(2024)
作者：Yue Qu, Jingna Gu, Lanxin Li, Yuqi Yan, Can Yan, Tiange Zhang
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子：4.8
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Neurotoxicity of Realgar: Crosstalk Between UBXD8-DRP1-Regulated Mitochondrial Fission and PINK1-Parkin-Mediated Mitophagy(2024)
作者：Feng Rui, Liu Jieyu, Yao Tiantian, Yang Zhao, Jiang Hong
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-024-04635-1
影响因子：4.6
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Irisflorentin improves functional recovery after spinal cord injury by protecting the blood–spinal cord barrier and promoting axonal growth(2024)
作者：Zhenxin Hu, Huixin Tan, Yu Zhang, Tengfei Qi, Yijun Li, Na Li, Ziheng Zhou, Yining Wang, Haoli Wang, Hongyu Zhang, Qingqing Wang
期刊：EXPERIMENTAL NEUROLOGY
DOI：10.1016/j.expneurol.2024.114886
影响因子：4.6
引用产品： 人脑微血管内皮细胞, PC-12 (High differentiation) 细胞
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Sports training improves motor function after spinal cord injury by regulating microtubule dynamics(2024)
作者：Yue Tang, Xiaohuan Wang, Mengjie Huang, Yijie Li, Xiaoxie Liu, Hong Zeng, Yanyan Yang, Mouwang Zhou
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2024.167587
影响因子：4.2
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Neuroprotective effects of trigonelline in eggplant on oxidative damage of PC12 cells and cognitive impairment in aging mice(2024)
作者：Jiahui Feng, Weihua Liu, Danqi Feng, Bimal Chitrakar, Xueping Chen, Yaxin Sang, Xianghong Wang
期刊：Journal of Functional Foods
影响因子：3.8
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Chlorogenic Acid Mitigates Ferroptosis by Activating the Nrf2/GPX4 Pathway through Keap1 Blockade in Vascular Dementia Rats(2024)
作者：Wen Shan, Guodong Liu, Chulei Deng, Yu Wei, Ke Ding
期刊：JOURNAL OF FOOD BIOCHEMISTRY
影响因子：3.5
引用产品： PC-12 (High differentiation) 细胞
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Q1:为什么我看的文献里的细胞培养条件和你们官网的培养条件不一样呢？
部分细胞是会出现多种培养条件的，我们公司优先选择引种来源的培养条件以及建系者所用培养条件，出现差异的原因是不同实验室在保藏过程中更改了细胞的培养条件，为了避免细胞突然更换培养条件后不适应，建议您优先使用厂家推荐的培养条件培养。
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