货号： CL-0050
Price： ￥1600 ￥1600
生长培养基： MEM（含NEAA）[PM150410]+20%FBS[164210]+1%P/S[PB180120]
产品信息
| 产品名称 | Caco-2（人结直肠腺癌细胞） |
| 别称 | CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 |
冻存液：55% 基础培养基+40% FBS+5% DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:MEM（含NEAA）[PM150410]+20%FBS[164210]+1%P/S[PB180120] 培养条件: 气相：空气，95%；CO₂，5%, 温度：37℃ |
| 培养方案B（可选） |
生长培养基: 培养条件: 气相：, 温度：37℃ |
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 |
|
参考资料(来源文献)
| 背景描述 | Caco-2细胞分离自直肠原位癌；当长到满时，Caco-2细胞表现出特征性的肠上皮细胞分化。Caco-2细胞表达维甲酸结合蛋白I和维甲酸结合蛋白Ⅱ，并呈角质蛋白阳性。 |
| 年龄（性别） | 72Y Male |
| 组织来源 | 结肠，结直肠腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肠癌细胞 |
| 生物安全等级 | BSL-1 |
| 致瘤性 | Yes, in nude mice; forms moderately well differentiated adenocarcinoma consistent with colonic primary (grade II). |
| 受体表达情况 | This cell line expressed heat stable enterotoxin (Sta, E. coli) and epidermal growth factor (EGF). |
STR位点信息
STR鉴定图
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2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice(2024)
作者：Xiaoxia Liu, Bowei Zhang, Yunhui Zhang, Wanhua Li, Jia Yin, Aiying Shi, Jin Wang, Shuo Wang
期刊：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
影响因子：6.1
引用产品： Caco-2 细胞
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Taurine Alleviates Experimental Colitis by Enhancing Intestinal Barrier Function and Inhibiting Inflammatory Response through TLR4/NF-κB Signaling(2024)
作者：Jiaming Zheng, Jinglin Zhang, Yewen Zhou, Di Zhang, Hongzhou Guo, Bin Li, Sheng Cui
期刊：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
影响因子：6.1
引用产品： Caco-2 细胞
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A microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression reveals physiological characteristics similar to depression.(2024)
作者：Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
期刊：LAB ON A CHIP
影响因子：6.1
引用产品： Caco-2 细胞
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Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion(2024)
作者：Lu Tianshu, Wu Tongchuan, Zhong Hao, Li Xue, Zhang Yunsen, Yue Hao, Dai Yulin, Li Haifeng, Ouyang Defang
期刊：Drug Delivery and Translational Research
DOI：10.1007/s13346-024-01628-4
影响因子：5.7
引用产品： Caco-2 细胞
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Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling(2024)
作者：Pengzhen Liang, Wei Xie, Xing Wang, Zhaohui Du, Chuanming Zheng, Hongchang Zhao, Zhenjie Wang, Zhong Ji
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.111900
影响因子：5.6
引用产品： Caco-2 细胞
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Study on the Anti-Ulcerative Colitis Effect of Pseudo-Ginsenoside RT4 Based on Gut Microbiota, Pharmacokinetics, and Tissue Distribution(2024)
作者：Hui Yu, Caixia Wang, Junzhe Wu, Qianyun Wang, Hanlin Liu, Zhuoqiao Li, Shanmei He, Cuizhu Wang, Jinping Liu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子：5.6
引用产品： Caco-2 细胞
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Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species(2024)
作者：Shuang He, Ting Zhang, Yuan-yi Wang, Wei Yuan, Li Li, Jin Li, Yue-yan Yang, Dong-ming Wu, Ying Xu
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.111570
影响因子：5.6
引用产品： Caco-2 细胞
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The structural characteristics of Crassostrea gigas peptide-zinc complexes and the bioactive mechanism of their enhanced zinc absorption(2024)
作者：Siyi Wang, Ximing Yang, Shuzhen Cheng, Ming Du
期刊：Food Bioscience
DOI：10.1016/j.fbio.2024.103722
影响因子：5.2
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Sucrose Stearates Stabilized Oil-in-Water Emulsions: Gastrointestinal Fate, Cell Cytotoxicity and Proinflammatory Effects after Simulated Gastrointestinal Digestion(2024)
作者：Danhong Zheng, Weiyan Guan, Jiaqing Chen, Cuicui Zeng, Shen Tan, Jing Chen, Da Ma
期刊：Foods
影响因子：5.2
引用产品： Caco-2 细胞, RAW 264.7 细胞
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Design of Auto-Adaptive Drug Delivery System for Effective Delivery of Peptide Drugs to Overcoming Mucus and Epithelial Barriers(2024)
作者：Ding Ruihuan, Li Yanping, Zheng Wei, Sun Yiying, Zhao Zhenyu, Zhang Houqian, Yuan Ranran, Wang Aiping, Sun Kaoxiang, Wang Hongbo, Shi Yanan
期刊：AAPS Journal
DOI：10.1208/s12248-024-00971-1
影响因子：5.0
引用产品： 青霉素-链霉素溶液（双抗），100×, MEM 培养基, 特级胎牛血清, Caco-2 细胞
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Q1:为什么我看的文献里的细胞培养条件和你们官网的培养条件不一样呢？
部分细胞是会出现多种培养条件的，我们公司优先选择引种来源的培养条件以及建系者所用培养条件，出现差异的原因是不同实验室在保藏过程中更改了细胞的培养条件，为了避免细胞突然更换培养条件后不适应，建议您优先使用厂家推荐的培养条件培养。
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